Know more

About cookies

What is a "cookie"?

A "cookie" is a piece of information, usually small and identified by a name, which may be sent to your browser by a website you are visiting. Your web browser will store it for a period of time, and send it back to the web server each time you log on again.

Different types of cookies are placed on the sites:

  • Cookies strictly necessary for the proper functioning of the site
  • Cookies deposited by third party sites to improve the interactivity of the site, to collect statistics

Learn more about cookies and how they work

The different types of cookies used on this site

Cookies strictly necessary for the site to function

These cookies allow the main services of the site to function optimally. You can technically block them using your browser settings but your experience on the site may be degraded.

Furthermore, you have the possibility of opposing the use of audience measurement tracers strictly necessary for the functioning and current administration of the website in the cookie management window accessible via the link located in the footer of the site.

Technical cookies

Name of the cookie


Shelf life

CAS and PHP session cookies

Login credentials, session security



Saving your cookie consent choices

12 months

Audience measurement cookies (AT Internet)

Name of the cookie


Shelf life


Trace the visitor's route in order to establish visit statistics.

13 months


Store the anonymous ID of the visitor who starts the first time he visits the site

13 months


Identify the numbers (unique identifiers of a site) seen by the visitor and store the visitor's identifiers.

13 months

About the AT Internet audience measurement tool :

AT Internet's audience measurement tool Analytics is deployed on this site in order to obtain information on visitors' navigation and to improve its use.

The French data protection authority (CNIL) has granted an exemption to AT Internet's Web Analytics cookie. This tool is thus exempt from the collection of the Internet user's consent with regard to the deposit of analytics cookies. However, you can refuse the deposit of these cookies via the cookie management panel.

Good to know:

  • The data collected are not cross-checked with other processing operations
  • The deposited cookie is only used to produce anonymous statistics
  • The cookie does not allow the user's navigation on other sites to be tracked.

Third party cookies to improve the interactivity of the site

This site relies on certain services provided by third parties which allow :

  • to offer interactive content;
  • improve usability and facilitate the sharing of content on social networks;
  • view videos and animated presentations directly on our website;
  • protect form entries from robots;
  • monitor the performance of the site.

These third parties will collect and use your browsing data for their own purposes.

How to accept or reject cookies

When you start browsing an eZpublish site, the appearance of the "cookies" banner allows you to accept or refuse all the cookies we use. This banner will be displayed as long as you have not made a choice, even if you are browsing on another page of the site.

You can change your choices at any time by clicking on the "Cookie Management" link.

You can manage these cookies in your browser. Here are the procedures to follow: Firefox; Chrome; Explorer; Safari; Opera

For more information about the cookies we use, you can contact INRAE's Data Protection Officer by email at or by post at :


24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal logos partenaires

Master Plant Sciences

Genome engineering and interfering RNAs

Plant Sciences platform

U. Paris-Saclay / U. Paris Cité

Université Paris-Saclay and Université Paris Cité common Teaching Unit


Christine LELANDAIS-BRIERE (Université Paris Cité).


Good level in molecular biology and cell biology with a general Bachelor's degree in Life Sciences.


The objectives of this course are:
1) to train students in the methodologies of genome engineering and editing, synthetic biology and RNA-mediated technologies, in particular gene silencing by RNA interference
2) to describe the molecular basis of the mechanisms of gene regulation mediated by non-coding RNAs and DNA repair/recombination underlying these technologies
3) to present prospective developments and applications in the fields of plant production and health
4) to reflect on the societal, environmental and ethical challenges associated with the development of these biotechnologies.


  • Lectures: Genome engineering technologies, synthetic biology and RNA interference: principles, underlying molecular mechanisms and applications.
  • Tutorials: examples of applications
  • Practicals: silencing in plants.
    During the practical work sessions, the students carry out the analysis of Arabidopsis thaliana lines subjected to different types of silencing and highlight the systemic response to a viral attack. They carry out cloning for an RNAi strategy. This work allows them not only to learn molecular biology techniques dedicated to the analysis of small interfering RNAs and DNA methylation, but also to practice classical transgenesis, molecular and plant cell biology techniques (quantitative RT-PCR, cloning, detection of reporter proteins...).
  • Seminars (4h)
  • Personal work: report on practical work, preparation of the seminars, turorials and the exam.


  • Biotechnologies. Les promesses du vivant, 2015, Vanessa Proux, Collectif, Fyp
  • Stable RNA interference rules for silencing, Fellmann and Lowe, 2014, Nature Cell Biology, vol 16
  • Synthetic biology: Recent progress, biosafety and biosecurity concerns, and possible solutions, Wang and Zhang, 2019, Journal of Biosafety and Biosecurity
  • The next generation of CRISPR–Cas technologies and applications, Pickar-Oliver & Gersbach, 2019, Nature Reviews Molecular Cell Biology volume 20, pages 490–507.

Elective TU (Choice between this TU "Genome engineering and interfering RNAs" and the TU "Plant nutrition physiology and agronomy").
Lectures: 14h, Tutorials: 6h, Practicals: 24h
Location: Paris